Deletions of recessive disease genes: CNV contribution to carrier states and disease-causing alleles
نویسندگان
چکیده
منابع مشابه
Tailor-made RNAi knockdown against triplet repeat disease-causing alleles.
Nucleotide variations, including SNPs, in the coding regions of disease genes are important targets for RNAi treatment, which is a promising medical treatment for intractable diseases such as triplet repeat diseases. However, the identification of such nucleotide variations and the design of siRNAs conferring disease allele-specific RNAi are quite difficult. In this study we developed a pull-do...
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Genes involved in disease that are not common are often difficult to identify; a method that pinpoints them from a small number of unrelated patients will be of great help. In order to establish such a method that detects recessive genes identical-by-descent, we modified homozygosity mapping (HM) so that it is constructed on the basis of homozygosity haplotype (HM on HH) analysis. An analysis u...
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ژورنال
عنوان ژورنال: Genome Research
سال: 2013
ISSN: 1088-9051
DOI: 10.1101/gr.156075.113